Tottenham host RB Leipzig in the first leg of their Champions League Round of 16 tie. The Tottenham Hotspur Stadium has seen more goals than any other venue in this season's UCL.
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Atalanta face Valencia in the first leg of their UEFA Champions League Round of 16 tie at the San Siro. This will be the first ever encounter between the two sides.
Manchester United face Belgian side Club Brugge in the first leg of their Europa League Round of 32 tie. United are unbeaten in their last 10 Europa League knockout stage games.
Celtic travel to Denmark to face Copenhagen in the first leg of their UEFA Europa League Round of 32 tie. Celtic's last away win against Danish opposition was in September 1983.
Mikel Arteta takes charge of his first European match as Arsenal manager as the Gunners face Olympiacos in the first leg of their UEFA Europa League Round of 32 tie.
Rangers host Braga at Ibrox Stadium in their Europa League Round of 32 first leg tie. This is Rangers' first appearance in the knockout stages of a European competition since 2011.
Wolves host Espanyol at Molineux in the first leg of their Europa League Round of 32 tie. Raúl Jiménez has been involved in 12 goals in 11 European games for Wolves this season.
St. Mirren host Hearts at St. Mirren Stadium in the Ladbrokes Scottish Premiership.
Chelsea and Tottenham go head-to-head in the Premier League as they meet at Stamford Bridge.
Sutton United host Barrow in the Vanarama National League at Borough Sports Ground.